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June 5, 2013Artificial Organs

Exposure to shear stresses above 20 Pa caused significant changes in all three platelet markers for human blood, whereas bovine blood markers did not change except for plasma serotonin in heparin anticoagulated blood.

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Why the study?

Does shear stress stimulation differentially activate platelets in human versus bovine blood?

Population

Fresh whole blood samples from humans and bovines, anticoagulated with heparin or anticoagulant citrate…

Comparison

Exposure to shear stresses up to 40 Pa for 2 min… vs Bovine blood compared to human blood

Design

Preclinical

Follow-up

2 min

Authors

QLQijin LuBHBryan V. HofferbertGKGrace Koo

Discussion

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Overview

Bovine models may underestimate human platelet activation by shear; leaves open validity of current hemocompatibility testing standards for cardiovascular devices.

Structured PICO

Does shear stress stimulation differentially activate platelets in human versus bovine blood?

P
Population
Fresh whole blood samples from humans and bovines, anticoagulated with heparin or anticoagulant citrate dextrose, solution A (ACDA)
I
Intervention
Exposure to shear stresses up to 40 Pa for 2 min using a cone-and-plate rheometer model
C
Comparator
Bovine blood compared to human blood
O
Outcome
Platelet activation characterized by platelet counts, platelet surface P-selectin expression, and serotonin release into blood plasmasurrogate

Human blood is significantly more sensitive to shear stress-induced platelet activation than bovine blood, indicating bovine models may be inadequate for testing medical device hemocompatibility.

Cite This Study

Lu et al. (2013) studied this question.

synapsesocial.com/papers/6a709db535aa2c282ce1efb8https://doi.org/10.1111/aor.12099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantification of Shear‐Induced Platelet Activation: High Shear Stresses for Short Exposure Time2015 · 88 citations
  2. 2An ex-vivo model of shear-rate-based activation of blood coagulation2017 · 5 citations
  3. 3Shear Stress-Induced Changes in Platelet Reactivity1978 · 36 citations
  4. 4Shear stress-induced platelet activation enhances blood coagulation more than adenosine diphosphate-induced activation2025
  5. 5“Shear induced platelet activation” - A critical reappraisal1985 · 66 citations