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July 1, 2002ASAIO Journal

Canine species showed distinctively shorter time values in all three parameters compared to other species including humans, while ovine and human blood showed similar PHT and CT values.

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Why the study?

How do platelet and coagulation functions measured by the Xylum Clot Signature Analyzer compare across bovine, ovine, canine, and human species?

Population

Bovine, ovine, canine, and human whole blood samples

Comparison

Measurement of global platelet and coagulation… vs Comparison across species

Design

Preclinical

Authors

MSManabu SatoHHHiroaki Harasaki

Discussion

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Overview

May favor ovine over canine models for human-like hemostasis in device testing; leaves open species-specific validation before broader adoption.

Structured PICO

How do platelet and coagulation functions measured by the Xylum Clot Signature Analyzer compare across bovine, ovine, canine, and human species?

P
Population
Bovine, ovine, canine, and human whole blood samples
I
Intervention
Measurement of global platelet and coagulation function using the Xylum Clot Signature Analyzer (CSA)
C
Comparator
Comparison across species (bovine, ovine, canine vs. human)
O
Outcome
Platelet mediated hemostasis time (PHT), collagen induced thrombus formation time (CITF), and clotting time (CT)surrogate

Canine blood demonstrates significantly faster coagulation than human blood, suggesting dogs are suboptimal models for cardiovascular implant testing, whereas ovine blood more closely mimics human hemostasis.

Limitations

  • High intermeasurement variation for CSA parameters, especially in PHT

Cite This Study

Sato et al. (2002) studied this question.

synapsesocial.com/papers/6a912e864710667e82f1241bhttps://doi.org/10.1097/00002480-200207000-00006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1State-of-the-Art Review : Evaluation of the Clot Signature Analyzer as a Hemostasis Test in Healthy Volunteers Exposed to Low Doses of Aspirin1999 · 7 citations
  2. 2Xylum CSA®: Automated System for Assessing Hemostasis in Simulated Vascular Flow1997 · 14 citations
  3. 3In Vitro Shear Stress‐Induced Platelet Activation: Sensitivity of Human and Bovine Blood2013 · 54 citations
  4. 4Evaluation of platelet aggregometry in dogs using the M ultiplate platelet analyzer: impact of anticoagulant choice and assay duration2012 · 45 citations
  5. 5Platelet function in dogs: breed differences and effect of acetylsalicylic acid administration2007 · 53 citations