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February 1, 2012Journal of Veterinary Emergency and Critical Care

Heparin may be the superior anticoagulant for Multiplate platelet aggregometry in dogs, as hirudin showed spontaneous autoaggregation and citrate yielded significantly lower aggregation.

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Why the study?

Does the choice of anticoagulant and assay duration affect platelet aggregometry results using the Multiplate analyzer in dogs?

Population

20 clinically healthy dogs and 3 ill dogs

Comparison

Blood samples collected in citrate, hirudin, or… vs Comparison between different anticoagulants and…

Design

Preclinical

Key result

Heparin may be the superior anticoagulant for Multiplate platelet aggregometry in dogs, as hirudin showed spontaneous autoaggregation and citrate yielded significantly lower aggregation.

Authors

CMClara B. MarschnerAKAnnemarie T. KristensenESEva H. Spodsberg

Discussion

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Overview

Should not change clinical veterinary practice; leaves open optimal anticoagulant selection for canine Multiplate testing.

Study Design

Type

Observational (n=23)

Multicenter

No

Structured PICO

Does the choice of anticoagulant and assay duration affect platelet aggregometry results using the Multiplate analyzer in dogs?

P
Population
Blood samples from 20 healthy and 3 ill dogs evaluated for platelet aggregometry using different anticoagulants.
E
Exposure
Blood samples collected in citrate, hirudin, or heparin, analyzed using adenosine diphosphate, collagen, and arachidonic acid as agonists
C
Comparator
Comparison between different anticoagulants (citrate, hirudin, heparin) and assay times
O
Outcome
Platelet aggregation response and analytical variationsurrogate

Heparin appears to be the superior anticoagulant for Multiplate platelet aggregometry analyses in dogs, whereas citrate is discouraged due to weak aggregation responses.

Cite This Study

Marschner et al. (2012) conducted an observational in Healthy and ill dogs (n=23). Anticoagulant choice (citrate, hirudin, heparin) and assay duration vs. Compared against each other was evaluated on Platelet aggregation response. Heparin may be the superior anticoagulant for Multiplate platelet aggregometry in dogs, as hirudin showed spontaneous autoaggregation and citrate yielded significantly lower aggregation.

synapsesocial.com/papers/6a962013538affa4349feab9https://doi.org/10.1111/j.1476-4431.2011.00709.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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