Enterovirus RNA is detectable in the PBMCs of a subset of patients at the onset of type 1 diabetes and is associated with HLA-DR4, suggesting a potential role in the disease's pathogenesis beyond acute infection.
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Hypothesis-generating for enteroviral role in T1D onset among HLA-DR4 carriers; prospective studies needed before clinical relevance.
Schulte et al. (2010) studied this question.
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