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ALTHOUGH the value of gamma globulin in the prevention of infectious hepatitis has repeatedly been shown1 2 3 4 5 6 the minimal effective dose remains to be determined. The increased demand for gamma globulin as a result of its use in the modification and prevention of poliomyelitis7 8 9 10 has made it essential to conserve this material whenever possible. The present paper concerns the use of small doses of gamma globulin in preventing the spread of infectious hepatitis in family outbreaks. Its use in institutional outbreaks will be discussed later.11 Stokes and Neefe1 first demonstrated the value of gamma globulin prepared from pooled human plasma in . . .
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Hsia et al. (1954) studied this question.
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