Why the study?
The study sought to determine how viral factors modulate innate immune signaling and cell death induction using mammalian reovirus as a model.
The reovirus σ3 protein plays a previously unknown role in limiting necroptosis by preventing excessive interferon production.
σ3 limits reovirus-induced necroptosis; leaves open broader roles in viral pathogenesis or host-targeted therapies.
We use mammalian reovirus as a model to study how virus infection modulates innate immune signaling and cell death induction. Here, we sought to determine how viral factors regulate these processes. Our work highlights a previously unknown role for the reovirus outer capsid protein σ3 in limiting the induction of a necrotic form of cell death called necroptosis. Induction of cell death by necroptosis requires production of interferon. The σ3 protein limits the induction of necroptosis by preventing excessive production of interferon following infection.
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Roebke et al. (2020) studied this question.
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