November 1, 1988Proceedings of the National Academy of SciencesOpen Access

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

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Population

Mouse L cells (grown as monolayers or in suspension) infected with reovirus serotype 1 (Lang) strain

Comparison

Reovirus serotype 1 infection and purified sigma… vs Uninfected cells and extracts without sigma 3…

Design

Preclinical

Authors

FIFarhad ImaniUniversity of Connecticut BJBertram L. JacobsArizona State University

Discussion

Member takes

Implication

Identifies sigma 3 as a reovirus PKR inhibitor in animal models; leaves open relevance to human antiviral responses or therapies.

Structured PICO

Population

Mouse L cells (grown as monolayers or in suspension) infected with reovirus serotype 1 (Lang) strain

Intervention

Reovirus serotype 1 infection and purified sigma 3 protein

Comparator

Uninfected cells and extracts without sigma 3 protein

Outcome

Inhibition of interferon-induced, double-stranded RNA (dsRNA)-dependent protein kinase activationsurrogate

The reovirus serotype 1 sigma 3 protein inhibits the interferon-induced, dsRNA-dependent protein kinase, providing a mechanism for viral evasion of host antiviral responses.

Cite This Study

Imani et al. (1988) studied this question.

synapsesocial.com/papers/6a83440ba5a7d01babae3526 https://doi.org/10.1073/pnas.85.21.7887

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Ask AI

Bookmark

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider