Why the study?
It is unclear how changes in FEV1 in the presence or absence of airflow limitation impact the intensity of dyspnea and leg effort during incremental exercise.
Population
38,788 consecutive patients over age 35 referred for cardiopulmonary exercise testing
Comparison
Presence vs absence of airflow limitation (FEV1/FVC < 70%)
Design
Retrospective cohort study
Authors
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Power and FEV1, not airflow limitation, primarily determine dyspnea and leg effort; leaves open whether muscle-strength interventions alter symptoms.
In patients undergoing cardio-pulmonary exercise testing, power, quadriceps strength, and FEV1 are the primary drivers of dyspnea and leg effort, regardless of the presence of airflow limitation.
Satia et al. (2020) studied this question.
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