October 1, 1997Journal of VirologyOpen Access

Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras

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Population

In vitro model assaying transfected UL41 alleles from HSV-1(KOS) and HSV-2(333)

Comparison

Transfection with HSV-2 UL41 allele or chimeric… vs Transfection with HSV-1(KOS) UL41 allele

Design

Preclinical

Authors

Discussion

Delineates HSV-2 vhs determinants; leaves open their impact on pathogenesis or antiviral strategies.

Population

In vitro model assaying transfected UL41 alleles from HSV-1(KOS) and HSV-2(333)

Intervention

Transfection with HSV-2(333) UL41 allele or chimeric UL41 alleles

Comparator

Transfection with HSV-1(KOS) UL41 allele

Outcome

Inhibition of cotransfected reporter gene expression (Vhs activity)surrogate

The study identifies specific amino acid regions responsible for the higher virion host shutoff activity of HSV-2 compared to HSV-1.

Everly et al. (1997) studied this question.

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