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August 2, 2022Scientific ReportsOpen Access

An explorative metabolomic analysis of the endothelium in pulmonary hypertension

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Why the study?

The pathological mechanisms underlying pulmonary hypertension remain elusive, though abnormal metabolic activities in the endothelium may play a crucial role.

Population

Patients with pulmonary hypertension

Design

Metabolomic analysis using genome-scale metabolic reconstruction

Authors

JCJørn CarlsenUniversity of CopenhagenHHH HenriksenUniversity of CopenhagenIMIgor Marín de MasNovo Nordisk Foundation

Discussion

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Implication

Endothelial metabolic phenotypes cluster independently of PH subtype and track with severity; leaves open whether profiling guides targeted therapy.

Structured PICO

P
Population
Patients with pulmonary hypertension, including group 1 (idiopathic pulmonary arterial hypertension and connective tissue disease-associated PAH) and group 4 (chronic thromboembolic pulmonary hypertension).
I
Intervention
Explorative metabolomic analysis using genome-scale metabolic reconstruction of the endothelial cell to investigate intracellular metabolism.
O
Outcome
Intracellular metabolic phenotypes of endothelial cells and their association with disease severity.surrogate

Endothelial cells in pulmonary hypertension exhibit four distinct metabolic phenotypes that correlate with disease severity, suggesting a potential new avenue for precision medicine and targeted therapeutic interventions.

Cite This Study

Carlsen et al. (2022) studied this question.

synapsesocial.com/papers/6a9136c780800acc7233f5b7https://doi.org/10.1038/s41598-022-17374-x
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Also Consider

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  1. 1Plasma Brain Natriuretic Peptide as a Prognostic Indicator in Patients With Primary Pulmonary Hypertension2000 · 878 citations
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