Why the study?
Does pressure-overload induced hypertrophy decrease the expression of calcium release channel mRNA in rat hearts?
Population
Rat model of severe left ventricular hypertrophy (>70%) induced by banding the abdominal aorta
Comparison
Pressure-overload induced hypertrophy vs Sham-operated control animals
Design
Preclinical
Authors
Loading...
Indicates potential calcium handling defects in rat LVH; leaves open translational relevance to human disease.
Does pressure-overload induced hypertrophy decrease the expression of calcium release channel mRNA in rat hearts?
Pressure-overload induced left ventricular hypertrophy in rats is associated with specific down-regulation of calcium release channel expression at the transcriptional level.
Michaels et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: