Why the study?
Does ventricular septal defect prevent the physiological regression of pulmonary artery medial thickness during postnatal development?
Does ventricular septal defect prevent the physiological regression of pulmonary artery medial thickness during postnatal development?
Patients with ventricular septal defect fail to undergo normal physiological regression of pulmonary artery medial thickness, which correlates with pulmonary hypertension and defect size.
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Failed medial regression in VSD associates with pulmonary pressure; leaves open whether early closure modifies arterial remodeling.
Honda et al. (1970) studied this question.
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