Why the study?
Does a diagnostic strategy incorporating D-dimer testing accurately exclude deep venous thrombosis compared to mandatory phlebography in patients with suspected DVT?
Does a diagnostic strategy incorporating D-dimer testing accurately exclude deep venous thrombosis compared to mandatory phlebography in patients with suspected DVT?
D-dimer testing demonstrates a high negative predictive value (91-96%) for excluding deep venous thrombosis in clinical practice, potentially reducing the need for mandatory phlebography.
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May support D-dimer rule-out of DVT in practice; leaves open need for RCTs before reducing phlebography.
Lindahl et al. (1998) studied this question.
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