Why the study?
Research on brown adipose tissue has focused mainly on thermogenesis, but brown adipose tissue-to-tissue communication via batokines could help elucidate future obesity treatments.
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Design
Review
Batokines expand BAT beyond thermogenesis as obesity targets; hypothesis-generating and requires prospective validation before clinical use.
PURPOSE OF REVIEW: This review highlights aspects of brown adipose tissue (BAT) communication with other organ systems and how BAT-to-tissue cross-talk could help elucidate future obesity treatments. RECENT FINDINGS: Until recently, research on BAT has focused mainly on its thermogenic activity. New research has identified an endocrine/paracrine function of BAT and determined that many BAT-derived molecules, termed "batokines," affect the physiology of a variety of organ systems and cell types. Batokines encompass a variety of signaling molecules including peptides, metabolites, lipids, or microRNAs. Recent studies have noted significant effects of batokines on physiology as it relates whole-body metabolism and cardiac function. This review will discuss batokines and other BAT processes that affect the liver, cardiovascular system, skeletal muscle, immune cells, and brown and white adipose tissue. Brown adipose tissue has a crucial secretory function that plays a key role in systemic physiology.
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A 2022 study studied this question.
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