Key result
Batokines, including FGF-21, VEGF-A, BMP8, NRG4, myostatin, and IL-6, act as endocrine signaling molecules that regulate metabolic homeostasis and emerge as therapeutic targets for treating obesity.
Why the study?
Brown adipocytes and batokines are emerging targets to treat obesity and comorbidities, warranting an outline of their systemic cross-talk and physiological significance.
Batokines secreted by brown adipose tissue act as endocrine signals that may serve as novel therapeutic targets for obesity and its metabolic comorbidities.
Batokines may influence cardiovascular homeostasis; leaves open their therapeutic targeting in obesity-related disease pending human trials.
Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are targets for treating obesity and its comorbidities. BAT shows high synthesis activity and secretes several signaling molecules. The brown adipokines, or batokines, take action in an autocrine, paracrine, and endocrine manner. Batokines have a role in the homeostasis of the cardiovascular system, central nervous system, white adipose tissue, liver, and skeletal muscle and exert beneficial effects on BAT. The systemic function of batokines gives BAT an endocrine organ profile. Besides, the batokines Fibroblast Growth Factor-21, Vascular Endothelial Growth Factor A, Bone Morphogenetic Protein 8, Neuregulin 4, Myostatin, and Interleukin-6 emerge as targets to treat obesity and its comorbidities, deserving attention. This review outlines the role of six emerging batokines on BAT and their cross-talk with other organs, focusing on their physiological significance and diet-induced changes.
No takes yet. Share an insight, caveat, or question.
Martins et al. (2022) conducted a review in Obesity and its comorbidities. Batokines was evaluated. Batokines, including FGF-21, VEGF-A, BMP8, NRG4, myostatin, and IL-6, act as endocrine signaling molecules that regulate metabolic homeostasis and emerge as therapeutic targets for treating obesity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: