Why the study?
Does sitagliptin improve the myocardial response to dobutamine stress and mitigate stunning in patients with coronary artery disease?
Population
14 patients with coronary artery disease and preserved LV function awaiting revascularization
Comparison
Single dose of 100 mg sitagliptin followed by 75… vs Placebo followed by 75 g of oral glucose prior…
Design
Other
Follow-up
30 minutes post-stress
Authors
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Does not support clinical use during stress testing; hypothesis-generating pilot data requiring confirmation in larger randomized trials.
Does sitagliptin improve the myocardial response to dobutamine stress and mitigate stunning in patients with coronary artery disease?
A single dose of sitagliptin improves global and regional left ventricular performance during dobutamine stress and mitigates postischemic stunning in patients with coronary artery disease.
Read et al. (2010) studied this question.
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