Why the study?
Does 17beta-estradiol prevent cardiac apoptosis in ovariectomized rats?
Population
48 female Wistar rats at 6-7 months of age (sham-operated n=16, bilateral ovariectomized n=32)
Comparison
17beta-estradiol 10 microg/kg/day injected… vs Saline injected intraperitoneally for 10 weeks…
Design
Preclinical
Follow-up
10 weeks
Authors
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Supports further preclinical exploration of estrogen's anti-apoptotic effects; should not change clinical practice pending human data.
Does 17beta-estradiol prevent cardiac apoptosis in ovariectomized rats?
Chronic 17beta-estradiol treatment prevents ovariectomy-induced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways in a rat model.
Liou et al. (2010) studied this question.
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