July 6, 2006AJP Endocrinology and Metabolism

Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation

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Population

Cultured rat heart-derived H9c2 cardiomyoblasts and excised hearts from Sprague-Dawley rats with 0- to…

Design

Preclinical

Follow-up

0 to 20 days

Authors

SLShin‐Da LeeChina Medical University CCChun‐Hsien ChuNational Cheng Kung University EHErh-Jung HuangZhejiang Sci-Tech University

Discussion

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Implication

No immediate clinical implications; leaves open IGF-II/IIR blockade as a target in ANG II-driven cardiomyocyte apoptosis.

Structured PICO

Population

Cultured rat heart-derived H9c2 cardiomyoblasts and excised hearts from Sprague-Dawley rats with 0- to 20-day complete abdominal aorta ligation (a model of ANG II elevation and hypertension)

Intervention

Various combinations of ANG II, IGF-II/IIR antibody, CsA, SP-600125, SB-203580, U-0126, or Staurosporine in H9c2 cells; abdominal aorta ligation in rats

Outcome

IGF-II/IIR expression, caspase activity, DNA fragmentation, and apoptotic cellssurrogate

IGF-II and its receptor play a critical role in ANG II-induced cardiomyoblast apoptosis via ERK, JNK, and calcineurin signaling pathways in a hypertensive rat model.

Cite This Study

Lee et al. (2006) studied this question.

synapsesocial.com/papers/6a913cea0f58508329fb575f https://doi.org/10.1152/ajpendo.00127.2005

Topics

Hypertension management

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Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider