Why the study?
Does AE0047 prevent or improve renal injury in stroke-prone spontaneously hypertensive rats compared to nitrendipine?
Population
Stroke-prone spontaneously hypertensive rats
Comparison
AE0047 for 6 weeks or 10 days vs Nitrendipine (10 and 30 mg/kg) and vehicle
Design
Preclinical
Follow-up
6 weeks (preventative study) and 10 days (therapeutic study)
Authors
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AE0047's renal effects in SHRSP warrant further preclinical study; leaves open translation to human hypertensive nephropathy.
Does AE0047 prevent or improve renal injury in stroke-prone spontaneously hypertensive rats compared to nitrendipine?
AE0047 demonstrates preventative and therapeutic effects against renal injury in stroke-prone spontaneously hypertensive rats, outperforming nitrendipine.
Hayashi et al. (1997) studied this question.
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