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July 28, 2020BMC Pregnancy and ChildbirthOpen Access

Burden of hepatitis E virus infection in pregnancy and maternofoetal outcomes: a systematic review and meta-analysis

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Why the study?

There is a dearth of knowledge on the burden of hepatitis E virus (HEV) infection in the global population of pregnant women.

Does HEV infection increase the risk of poor maternofoetal outcomes in pregnant women?

Population

11,663 pregnant women across 52 included studies

Comparison

HEV infection vs no HEV infection, or symptomatic vs asymptomatic women

Design

Systematic review and meta-analysis of cross-sectional, case-control, and cohort studies

Authors

JBJean Joël BignaYahoo (United Kingdom)AMAbdou Fatawou ModiyinjiCentre Pasteur du CamerounJNJobert Richie NansseuGeneral / Preventive / Lipids

Discussion

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Member takes

Overview

HEV seroprevalence and adverse maternofoetal outcomes in endemic areas support targeted screening; leaves open causal confirmation and intervention trials.

Structured PICO

Does HEV infection increase the risk of poor maternofoetal outcomes in pregnant women?

P
Population
11,663 pregnant women from 52 cross-sectional, case-control, and cohort studies
I
Intervention
Hepatitis E virus (HEV) infection
C
Comparator
No HEV infection
O
Outcome
HEV seroprevalence and maternofoetal outcomes (maternal deaths, low birth weight, small for gestational age, preterm birth, stillbirth, intrauterine deaths, miscarriage)hard clinical

HEV infection during pregnancy is associated with significantly increased risks of maternal death, preterm birth, and stillbirth, highlighting the need for preventive strategies in endemic areas.

Cite This Study

Bigna et al. (2020) studied this question.

synapsesocial.com/papers/6a913e80ae2c4ed52ef1289ehttps://doi.org/10.1186/s12884-020-03116-2
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Also Consider

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  1. 1Meta-analysis of prevalence2013 · 2,234 citations
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  3. 3Aetiology and prognostic factors in acute liver failure in India2003 · 177 citations
  4. 4Reduced glutathione in hepatitis E infection and pregnancy outcome2016 · 22 citations
  5. 5Hepatitis E virus seroprevalence in pregnant women in Pakistan: maternal and fetal outcomes2017 · 22 citations