β‐Adrenoceptor‐mediated inhibition of α1‐adrenoceptor‐mediated and field stimulation‐induced contractile responses in the prostate of the guinea pig

John M. Haynes; Stephen J. Hill

doi:10.1038/sj.bjp.0701494

November 1, 1997British Journal of PharmacologyOpen Access

β‐Adrenoceptor‐mediated inhibition of α1‐adrenoceptor‐mediated and field stimulation‐induced contractile responses in the prostate of the guinea pig

View Full Paper

Ask AI

Bookmark

Share

Structured PICO

P

Population

Guinea pig prostate preparations

I

Intervention

Beta-adrenoceptor agonists and antagonists (isoprenaline, propranolol, atenolol, ICI 118,551) and alpha1-adrenoceptor agonists/antagonists (phenylephrine, 5-methylurapidil)

O

Outcome

Contractile responses to electrical field-stimulation and phenylephrine, and accumulation of [3H]-inositol phosphate and [3H]-cAMPsurrogate

Beta 1- and beta 2-like adrenoceptors modulate alpha 1-adrenoceptor mediated and field stimulation-induced contractions in the guinea pig prostate.

Implication

Guinea pig data suggest beta-adrenoceptor inhibition of prostatic alpha1 responses; leaves open translation to human lower urinary tract symptoms.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Haynes et al. (1997) studied this question.

synapsesocial.com/papers/6a9140e76d69645d56f0728e https://doi.org/10.1038/sj.bjp.0701494

View Full Paper

Ask AI

Bookmark

Share

β‐Adrenoceptor‐mediated inhibition of α1‐adrenoceptor‐mediated and field stimulation‐induced contractile responses in the prostate of the guinea pig

Structured PICO

Implication

Discussion

Cite This Study

β‐Adrenoceptor‐mediated inhibition of α1‐adrenoceptor‐mediated and field stimulation‐induced contractile responses in the prostate of the guinea pig

Structured PICO

Implication

Discussion

Cite This Study

Keep reading

Keep reading