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August 28, 2026npj VirusesOpen Access

Crimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadth

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Authors

AWAlbert WangSMStephanie R. MonticelliJBJacob Berrigan

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Overview

Preclinical study reveals that M18-China GP38 elicits cross-reactive immunity in mice, indicating potential value as a component in broadly protective Crimean-Congo hemorrhagic fever vaccines.

Key Points

  • To investigate whether recombinant GP38 proteins can induce protective immune responses against diverse Crimean-Congo hemorrhagic fever virus clades in an animal model.
  • Engineered recombinant GP38 immunogens derived from six distinct clades of Crimean-Congo hemorrhagic fever virus.
  • Immunized mice with isolate M18-China GP38 to evaluate cross-reactive antibody responses, identify associated sequence motifs, and assess protective efficacy.
  • Isolate M18-China GP38 induced broad immunological cross-reactivity across divergent clades in mice despite exhibiting lower amino acid sequence similarity.
  • Immunization with M18-China GP38 alone did not confer complete protection against viral challenge in isolation.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a914599d15324a1df3a8ed6https://doi.org/10.1038/s44298-026-00230-4
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