What does this research mean for the field?

Ocular complications from facial dermal filler injections result in permanent vision loss in 57% of cases and brain infarction in 27% of cases, with no significant difference in visual outcomes across different filler types. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the spectrum of ocular complications and quantify the rates of permanent vision loss and brain infarction following facial dermal filler injections.

August 28, 2026F1000ResearchOpen Access

Ocular complications following facial dermal filler injections: a systematic review and proportion meta-analysis of visual and neurologic outcomes

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To evaluate the spectrum of ocular complications and quantify the rates of permanent vision loss and brain infarction following facial dermal filler injections.
Systematic review and random-effects proportion meta-analysis of 16 studies involving 81 patients identified across PubMed/MEDLINE, Scopus, and Web of Science.
Assessed study quality using Joanna Briggs Institute tools and pooled complication rates via logit transformation across various filler types and anatomical injection sites.
Ophthalmic artery occlusion and central retinal artery occlusion were the most common adverse events, with a pooled permanent vision loss proportion of 0.57 (95% CI, 0.45–0.68).
Brain infarction occurred in a pooled proportion of 0.27 (95% CI, 0.19–0.38) of patients.
Permanent vision loss did not differ significantly between autologous fat, hyaluronic acid, and mixed fillers (χ² = 0.22, p = 0.9738), with the glabella and nasal regions representing the highest-risk injection sites.

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Implication

Systematic review and meta-analysis finds high rates of permanent blindness and brain infarction after facial dermal fillers, highlighting severe vascular risks across all filler types.

Cite This Study

Alshehri et al. (2026) studied this question.

synapsesocial.com/papers/6a9145c5d15324a1df3a8fb4 https://doi.org/10.12688/f1000research.188879.1

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Implication

Systematic review and meta-analysis finds high rates of permanent blindness and brain infarction after facial dermal fillers, highlighting severe vascular risks across all filler types.

Ocular complications following facial dermal filler injections: a systematic review and proportion meta-analysis of visual and neurologic outcomes

Key Points

Discussion

Implication

Cite This Study

Ocular complications following facial dermal filler injections: a systematic review and proportion meta-analysis of visual and neurologic outcomes

Key Points

Discussion

Implication

Cite This Study

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