What does this research mean for the field?

An integrated approach utilizing molecular, epigenetic, microbial, and liquid biopsy biomarkers is essential for advancing personalized prognosis and precision therapy in colorectal cancer. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To critically evaluate established and emerging molecular biomarkers in colorectal cancer, examining their mechanistic roles and translational potential in precision oncology.

August 28, 2026Biomarkers

Integrated Molecular, Epigenetic, Microbial, and Liquid Biopsy Biomarkers in Colorectal Cancer: Implications for Prognosis and Precision Therapy

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Authors

SBSuvarna Bhokare AWAnita Wagh PJPrashant Jadhav

Discussion

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Overview

Narrative review evaluates molecular, microbial, and liquid biopsy biomarkers in colorectal cancer, highlighting strategies to optimize personalized prognosis and targeted therapy.

Key Points

To critically evaluate established and emerging molecular biomarkers in colorectal cancer, examining their mechanistic roles and translational potential in precision oncology.
Conducted a comprehensive narrative literature review of oncogenic pathways, regulatory microRNAs, gut microbiota dysbiosis, and liquid biopsy modalities.
Key genetic alterations—including APC-driven Wnt/β-catenin dysregulation, TP53 inactivation, KRAS and BRAF mutations, PI3K/AKT alterations, and microsatellite instability—drive tumor progression and dictate therapy resistance.
Regulatory microRNAs and gut microbiome imbalances significantly influence cancer progression and immune evasion.
Liquid biopsy platforms, primarily circulating tumor cells and cell-free DNA, provide minimally invasive tools for real-time monitoring of disease dynamics.

Cite This Study

Bhokare et al. (2026) studied this question.

synapsesocial.com/papers/6a9145ead15324a1df3a91af https://doi.org/10.1080/1354750x.2026.2715050

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August 28, 2026Biomarkers

Integrated Molecular, Epigenetic, Microbial, and Liquid Biopsy Biomarkers in Colorectal Cancer: Implications for Prognosis and Precision Therapy

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Authors

SBSuvarna Bhokare AWAnita Wagh PJPrashant Jadhav

Discussion

Member takes

Overview

Narrative review evaluates molecular, microbial, and liquid biopsy biomarkers in colorectal cancer, highlighting strategies to optimize personalized prognosis and targeted therapy.

Key Points

To critically evaluate established and emerging molecular biomarkers in colorectal cancer, examining their mechanistic roles and translational potential in precision oncology.
Conducted a comprehensive narrative literature review of oncogenic pathways, regulatory microRNAs, gut microbiota dysbiosis, and liquid biopsy modalities.
Key genetic alterations—including APC-driven Wnt/β-catenin dysregulation, TP53 inactivation, KRAS and BRAF mutations, PI3K/AKT alterations, and microsatellite instability—drive tumor progression and dictate therapy resistance.
Regulatory microRNAs and gut microbiome imbalances significantly influence cancer progression and immune evasion.
Liquid biopsy platforms, primarily circulating tumor cells and cell-free DNA, provide minimally invasive tools for real-time monitoring of disease dynamics.

Cite This Study

Bhokare et al. (2026) studied this question.

synapsesocial.com/papers/6a9145ead15324a1df3a91af https://doi.org/10.1080/1354750x.2026.2715050

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