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August 28, 2026Journal of Animal ScienceOpen Access

Evaluation of dietary Bacillus -based commercial probiotics in broiler chickens

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Authors

VVViet Anh VuKonkuk UniversitySKSoo-Ki KimKonkuk UniversityHBHuy Doanh BuiNational Institute of Animal Sciences

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Overview

Randomized trial demonstrates that Bacillus probiotics improve feed efficiency and intestinal gene expression in broiler chickens, suggesting additive benefits for gut integrity.

Key Points

  • To evaluate the effects of dietary supplementation with Bacillus subtilis, Bacillus licheniformis, and their combination on growth performance, gut health, nutrient digestibility, and intestinal gene expression in broiler chickens.
  • A 35-day randomized trial assigned 288 day-old Ross 308 broiler chicks to four dietary treatments across six replicate pens (12 birds per pen) in an environmentally controlled facility.
  • Diets consisted of a basal control, Bacillus subtilis at 5.0 × 10^7 cfu/kg, Bacillus licheniformis at 1.0 × 10^8 cfu/kg, or an equal combination blend at 2.0 × 10^8 cfu/kg.
  • Sampling occurred on days 21 and 35 to evaluate growth performance, ileal morphology, serum markers, cecal volatile fatty acids, nutrient digestibility, and intestinal mRNA expression.
  • Dietary Bacillus subtilis and the combination blend improved starter feed conversion ratio by 7.83% and 5.22%, respectively, with the blend reducing overall feed conversion ratio by 1.99% compared to controls (all P < 0.05).
  • At day 21, the probiotic blend increased the ileal villus height-to-crypt depth ratio by 40.66% and decreased ileal mucosal glutathione peroxidase activity by 38.06% relative to controls (P < 0.05).
  • Bacillus licheniformis and the combination blend upregulated ileal expression of tight junction proteins, mucin, antioxidant enzymes, and nutrient transporters by 2.0- to 4.0-fold on days 21 and 35 (P < 0.05).

Cite This Study

Vu et al. (2026) studied this question.

synapsesocial.com/papers/6a914622d15324a1df3a9727https://doi.org/10.1093/jas/skag269
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