What does this research mean for the field?

Low preoperative adiponectin levels are independently associated with the development of postoperative systemic inflammatory response syndrome (SIRS), but not postoperative complications, following major colorectal cancer surgery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the ability of perioperative adiponectin, interleukin-6, and routine inflammatory markers to predict postoperative systemic inflammatory response syndrome and complications after colorectal cancer surgery.

August 28, 2026Intensive Care Medicine ExperimentalOpen Access

Low preoperative adiponectin levels are associated with postoperative systemic inflammatory response following major colorectal cancer surgery

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Authors

SŠSonja ŠkiljićKlinički bolnički centar Osijek IŠInes ŠahinovićUniversity of Dubrovnik GKGordana KristekKlinički bolnički centar Osijek

Discussion

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Implication

Prospective observational study reveals low preoperative adiponectin predicts systemic inflammatory response syndrome in colorectal cancer surgery, highlighting its potential protective role.

Key Points

To evaluate the ability of perioperative adiponectin, interleukin-6, and routine inflammatory markers to predict postoperative systemic inflammatory response syndrome and complications after colorectal cancer surgery.
Conducted a prospective observational study of 57 patients scheduled for open colorectal cancer surgery.
Measured preoperative, 24-hour, and 72-hour postoperative levels of white blood cell count, C-reactive protein, interleukin-6, and adiponectin.
Classified patients by the presence of systemic inflammatory response syndrome (SIRS) within 72 hours and recorded complications until discharge.
Patients developing postoperative SIRS exhibited significantly lower preoperative adiponectin levels than those who did not (10.1 [5.3–15.1] vs. 14.7 [9.6–20.9] mg/L, p = 0.02).
Preoperative adiponectin was the only independent biomarker associated with SIRS in multivariate logistic regression (OR 0.91, 95% CI 0.83–0.99, p = 0.03; AUC 0.673, 95% CI 0.534–0.812, p = 0.01 at ≤ 7.5 mg/L).
Interleukin-6 measured at 72 hours postoperatively best predicted complications, with an AUC of 0.736 (95% CI 0.593–0.880, p = 0.001; sensitivity 66.7%, specificity 84.6% at ≥ 40.4 pg/mL).

Cite This Study

Škiljić et al. (2026) studied this question.

synapsesocial.com/papers/6a914622d15324a1df3a976d https://doi.org/10.1186/s40635-026-00960-y

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Implication

Prospective observational study reveals low preoperative adiponectin predicts systemic inflammatory response syndrome in colorectal cancer surgery, highlighting its potential protective role.

Low preoperative adiponectin levels are associated with postoperative systemic inflammatory response following major colorectal cancer surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

Low preoperative adiponectin levels are associated with postoperative systemic inflammatory response following major colorectal cancer surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

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