Key result
Day 1 postoperative IL-6 >432 pg/mL linked to ~230% greater risk of 30-day complications.
Why the study?
Major abdominal surgery carries a high postoperative morbidity and mortality rate, and inflammation is suggested to be associated with unfavorable outcomes.
Does a high postoperative IL-6 level on day 1 predict complications within 30 days in patients undergoing major abdominal surgery?
Population
137 patients undergoing major abdominal surgery
Comparison
Postoperative IL-6 level >432 pg/mL on day 1 vs ≤432 pg/mL on day 1
Design
Observational cohort study
Follow-up
30 days
Authors
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May support early risk stratification after major abdominal surgery; leaves open whether IL-6-guided care improves outcomes.
Observational (n=137)
Does a high postoperative IL-6 level on day 1 predict complications within 30 days in patients undergoing major abdominal surgery?
Odds Ratio: 3.3 (95% CI 1.3–8.5)
A high IL-6 level on postoperative day 1 is associated with an increased risk of complications after major abdominal surgery and can help distinguish high-risk patients earlier than CRP.
Rettig et al. (2015) conducted an observational in major abdominal surgery (n=137). IL-6 level > 432 pg/mL on day 1 was evaluated on composite of mortality, pneumonia, sepsis, anastomotic dehiscence, wound infection, noncardiac respiratory failure, atrial fibrillation, congestive heart failure, myocardial infarction, and reoperation within 30 days of surgery (adjusted OR 3.3, 95% CI 1.3-8.5). An IL-6 level >432 pg/mL on postoperative day 1 was associated with an increased risk of 30-day complications (adjusted OR 3.3; 95% CI 1.3-8.5).
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