What question did this study set out to answer?

To evaluate the pathologic features and patterns of tumor spread using whole-organ sectioning in patients undergoing salvage surgery for persistent or recurrent T3N0M0 glottic carcinoma after radical radiotherapy.

December 1, 1988Clinical Otolaryngology

T3N0M0glottic carcinoma?a pathologic analysis of 41 patients treated surgically following radiotherapy

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Authors

RGRalph GilbertPrincess Margaret Cancer Centre JLJan LundgrenLinköping University ANA. W. Peter Van NostrandUniversity of Toronto

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Implication

Retrospective cohort study reveals extensive pathologic upstaging in recurrent T3N0M0 glottic carcinoma after radiation, highlighting the need for wide surgical resections.

Key Points

To evaluate the pathologic features and patterns of tumor spread using whole-organ sectioning in patients undergoing salvage surgery for persistent or recurrent T3N0M0 glottic carcinoma after radical radiotherapy.
Analyzed whole-organ laryngeal serial sections from N=41 patients with initial T3N0M0 glottic carcinoma treated with radical radiotherapy (50-55 Gy over 4-5 weeks) who subsequently underwent salvage surgery for radiation failure.
Evaluated pathologic restaging (rpT), surgical margins, cartilage invasion, vascular/perineural invasion, subglottic extension, and presence of osteoradionecrosis or occult nodal disease.
Pathologic restaging classified 58% of tumors as rpT4, 29% as rpT3, and the remainder as rpT0-2.
Major cartilage invasion, vascular or perineural invasion, and subglottic extension greater than 15 mm occurred significantly more often in patients with locoregional recurrence (P < 0.001), yielding a positive predictive value of 0.78 for locoregional failure.
Surgical margins were positive in 19% of cases, osteo-chondroradionecrosis was identified in 23%, and occult nodal metastases were absent (0%) among patients undergoing neck dissection.

Cite This Study

Gilbert et al. (1988) studied this question.

synapsesocial.com/papers/6a9147131ff55ae0aec65612 https://doi.org/10.1111/j.1365-2273.1988.tb00320.x

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Implication

Retrospective cohort study reveals extensive pathologic upstaging in recurrent T3N0M0 glottic carcinoma after radiation, highlighting the need for wide surgical resections.

T3N0M0glottic carcinoma?a pathologic analysis of 41 patients treated surgically following radiotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

T3N0M0glottic carcinoma?a pathologic analysis of 41 patients treated surgically following radiotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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