What question did this study set out to answer?

To evaluate survival and local control outcomes in patients with T3N0M0 glottic carcinoma treated with primary radiotherapy and salvage surgery.

T3N0M0glottic carcinoma?a failure analysis

View Full Paper

Ask AI

Bookmark

Authors

Cohort study reveals 50.5% five-year survival following primary radiotherapy in glottic carcinoma, indicating sex and age influence local control.

To evaluate survival and local control outcomes in patients with T3N0M0 glottic carcinoma treated with primary radiotherapy and salvage surgery.
Retrospective cohort analysis of 141 patients presenting clinically with T3N0M0 glottic carcinoma between 1964 and 1981.
Patients received primary radiotherapy, with surgical intervention reserved for recurrent or residual disease.
The 5-year actuarial survival was 50.5%, with 28% of patients dying of glottic cancer and 59% of 5-year survivors retaining a functioning larynx.
Local relapse-free rates were significantly higher in female patients (68%) than male patients (41%) (P = 0.04), and higher in males aged ≥60 years (46%) than males aged ≤59 years (31%) (P = 0.02).
High primary failure rates were associated with initial tracheotomy and involvement of all three laryngeal regions, whereas endoscopy frequency and time to recurrence had no significant survival impact.

Lundgren et al. (1988) studied this question.

View Full Paper

Ask AI

Bookmark

Cohort study reveals 50.5% five-year survival following primary radiotherapy in glottic carcinoma, indicating sex and age influence local control.