What question did this study set out to answer?

Assess the methodological validity of inferring neurohypophysial hormone release from target organ responses during in vivo stimulation.

June 1, 1968British Journal of Pharmacology and ChemotherapyOpen Access

Stimuli for the Release of Neurohypophysial Hormones

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Assess the methodological validity of inferring neurohypophysial hormone release from target organ responses during in vivo stimulation.
Reviewed experimental literature evaluating in vivo stimuli that induce the release of vasopressin and oxytocin.
Analyzed confounding physiological responses caused by the simultaneous release of other endogenous substances and cardiovascular changes.
Target-organ responses often misrepresent neurohypophysial activity because experimental stimuli can concurrently release adrenaline, which blocks oxytocin release, masks its mammary actions, and alters vasopressin dynamics.
Non-hormonal variables such as blood pressure fluctuations and secondary vasoactive agents (including bradykinin, angiotensin, and substance P) induce antidiuresis independently through cardiovascular mechanisms.

Authors

RDR. E. J. DyballUniversity of Cambridge

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Implication

Narrative review reveals confounding factors in measuring neurohypophysial hormone release in vivo, suggesting target-organ responses frequently misrepresent direct endocrine activity.

Cite This Study

R. E. J. Dyball (1968) studied this question.

synapsesocial.com/papers/6a9147611ff55ae0aec65651 https://doi.org/10.1111/j.1476-5381.1968.tb00993.x

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Implication

Narrative review reveals confounding factors in measuring neurohypophysial hormone release in vivo, suggesting target-organ responses frequently misrepresent direct endocrine activity.

Stimuli for the Release of Neurohypophysial Hormones

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Discussion

Implication

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Stimuli for the Release of Neurohypophysial Hormones

Key Points

Discussion

Implication

Cite This Study

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