Optimal In-Hospital and Discharge Medical Therapy in Acute Coronary Syndromes in Kerala
Why the study?
Does optimal in-hospital and discharge medical therapy reduce in-hospital death and MACE in patients with acute coronary syndromes?
Population
25,718 admissions for acute coronary syndrome (ACS) in the Kerala ACS Registry, India.
Comparison
Optimal in-hospital medical therapy and optimal… vs Nonoptimal ACS care.
Design
Cohort
Follow-up
In-hospital
Authors
Discussion
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Member takes
Implication
Supports optimization efforts in ACS; hypothesis-generating and requires RCTs before practice change.
Structured PICO
Does optimal in-hospital and discharge medical therapy reduce in-hospital death and MACE in patients with acute coronary syndromes?
P
Population
25,718 admissions for acute coronary syndrome (ACS) in the Kerala ACS Registry, India.
I
Intervention
Optimal in-hospital medical therapy (aspirin, clopidogrel, heparin, beta-blocker, and statin) and optimal discharge medical therapy (aspirin, clopidogrel, beta-blocker, and statin).
C
Comparator
Nonoptimal ACS care (not receiving the full package of optimal medications).
O
Outcome
In-hospital death and major adverse cardiovascular event (MACE) rates.hard clinical
Delivery of optimal medical therapy for ACS remains low in Kerala, India, but when provided, it is associated with a significant reduction in major adverse cardiovascular events.
Cite This Study
Huffman et al. (2013) studied this question.