Hepatitis After Repeated Exposure to Halothane

Case Studies1 October 1966Hepatitis After Repeated Exposure to HalothaneCase Report and Brief ReviewPAUL F. GRINER, M.D.PAUL F. GRINER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-753 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the 10 years that have elapsed since the introduction of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) as an anesthetic agent, the issue of whether an association exists between its administration and subsequent hepatic dysfunction remains unresolved despite a large body of literature addressed to this point (1-16).Isolated instances of death from massive hepatic necrosis after halothane exposure form the majority of reports. A causal relationship has been difficult to establish because of such complicating features as serious intercurrent illness, the administration of multiple drugs, and shock.Repeated episodes of hepatic dysfunction after multiple exposures to halothane (in the same patient) lend greater...References1. LINDENBAUMLEIFER JE: Hepatic necrosis associated with halothane anesthesia. New Eng. J. Med. 268: 525, 1963. CrossrefMedlineGoogle Scholar2. TYGSTRUP N: Halothane hepatitis (letter to the editor). Lancet 2: 466, 1963. CrossrefGoogle Scholar3. BLACKBURNNGAILINDENBAUM WRSHJ: Morphologic changes in hepatic necrosis following halothane anesthesia in man. Anesthesiology 25: 270, 1964. CrossrefMedlineGoogle Scholar4. SHERLOCK S: Halothane and the liver. Proc. Roy. Soc. Med. 57: 305, 1964. CrossrefMedlineGoogle Scholar5. COOKSHERLOCK GCS: Jaundice and its relation to therapeutic agents. Lancet 1: 175, 1965. CrossrefMedlineGoogle Scholar6. 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DYKESWALZERSLATERGIBSONELLIS MHSGEMJMDS: Acute parenchymatous hepatic disease following general anesthesia: clinical appraisal of hepatotoxicity following administration of halothane. JAMA 193: 339, 1965. CrossrefMedlineGoogle Scholar12. SLATERGIBSONDYKESCHIRWALZER EMJMMHBSG: Postoperative hepatic necrosis. Its incidence and diagnostic value in association with the administration of halothane. New Eng. J. Med. 270: 983, 1964. CrossrefMedlineGoogle Scholar13. MUSHINROSENBOWENCAMPBELL WWMDJH: Halothane and liver dysfunction: a retrospective study. Brit. Med. J. 2: 329, 1964. CrossrefMedlineGoogle Scholar14. BUNKERBLUMENFELD JPCM: Liver necrosis after halothane anesthesia. Cause or coincidence? New Eng. J. Med. 268: 531, 1963. CrossrefMedlineGoogle Scholar15. BRODYSWEET GLRB: Halothane anesthesia as a possible cause of massive hepatic necrosis. Anesthesiology 24: 29, 1963. CrossrefMedlineGoogle Scholar16. VIRTUEPAYNE RWKW: Postoperative death after Fluothane. Anesthesiology 19: 562, 1958. CrossrefMedlineGoogle Scholar17. SCHULTZADAMSONWORKMANNORMAN JCJSWWTD: Fatal liver disease after intravenous administration of tetracycline in high dosage. New Eng. J. Med. 269: 999, 1963. CrossrefMedlineGoogle Scholar18. POPPERKLATSKINDRILLBRODIEMAGEEBOLLMANSCHMIDTSCHAFFNERSHAYSHERLOCKARCHER HGVABBPNJEFHSJD: Symposium on toxic hepatic injury (abstract). Gastroenterology 38: 786, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL F. GRINER, M.D.Affiliations: Rochester, New YorkFrom the Department of Medicine, Rochester General Hospital and the University of Rochester School of Medicine and Dentistry, Rochester, N. Y.Requests for reprints should be addressed to Paul F. Griner, M.D., Department of Medicine, Rochester General Hospital, 1425 Portland Ave., Rochester, N. Y. 14621. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatotoxicity: Pathogenesis and Therapeutic InterventionFanconi syndrome following bowel surgery and hepatitis reversed by 25-hydroxycholecalciferolRetinal Detachment, Halothane, and HepatitisFatal Halothane Hepatitis with Transient GranulomasHepatitis After Exposure to HalothaneFRANKLIN M. KLION, M.D., FENTON SCHAFFNER, M.D., F.A.C.P., HANS POPPER, M.D., F.A.C.P.Renal and Hepatic Injury Associated with Methoxyflurane AnesthesiaSTEPHEN G. ELKINGTON, M.D., JOHN A. GOFFINET, M.D., HAROLD O. CONN, M.D.Fulminant Hepatic Failure 1 October 1966Volume 65, Issue 4Page: 753-757KeywordsAnestheticsDentistryDrug administrationDrugsEosinophiliaHepatitis AHospital medicineNecrosisRisk managementShock ePublished: 1 December 2008 Issue Published: 1 October 1966 PDF downloadLoading ...