Key result
Sustained-release isosorbide dinitrate significantly decreased left atrial pressure in dogs with mitral valve regurgitation at 4 hours post-dose (21.3 to 13.6 mmHg for 10 mg/kg, P<0.001).
Why the study?
Does sustained-release isosorbide dinitrate reduce left atrial pressure in dogs with experimentally induced mitral valve regurgitation?
RCT (n=6)
Randomized
Does sustained-release isosorbide dinitrate reduce left atrial pressure in dogs with experimentally induced mitral valve regurgitation?
Absolute Event Rate: 13.6% vs 21.3%
p-value: p=<.001
Sustained-release isosorbide dinitrate dose-dependently reduces left atrial pressure in a canine model of mitral regurgitation.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating in experimental canine mitral regurgitation; leaves open translation to clinical practice.
Yamamoto et al. (2013) conducted an RCT in Mitral valve regurgitation (n=6). Sustained-release isosorbide dinitrate (sr-ISDN) vs. Placebo was evaluated on Left atrial pressure (LAP) (p=<.001). Sustained-release isosorbide dinitrate significantly decreased left atrial pressure in dogs with mitral valve regurgitation at 4 hours post-dose (21.3 to 13.6 mmHg for 10 mg/kg, P<0.001).