Key result
Modified-vertebral left atrial size (M-VLAS) provided an area under the curve of 0.97, which was superior to vertebral heart size (AUC 0.90, P=0.03) in identifying left atrial enlargement in dogs.
Why the study?
In the absence of echocardiography, thoracic radiography is necessary to identify cardiomegaly for MMVD severity classification, and whether modified-vertebral left atrial size (M-VLAS) identifies left atrial enlargement more accurately than existing methods required evaluation.
Does M-VLAS improve the radiographic identification of left atrial enlargement compared to existing methods in dogs with myxomatous mitral valve disease?
Case-Control (n=70)
Single-blind
Yes
Does M-VLAS improve the radiographic identification of left atrial enlargement compared to existing methods in dogs with myxomatous mitral valve disease?
Absolute Event Rate: 0.97% vs 0.9%
p-value: p=0.03
M-VLAS provides a highly accurate and repeatable 2-dimensional radiographic method to identify left atrial enlargement in dogs with myxomatous mitral valve disease, outperforming standard vertebral heart size.
M-VLAS may aid radiographic LA assessment in MMVD dogs; hypothesis-generating from retrospective data and requires prospective validation.
BACKGROUND: In the absence of echocardiography, identification of cardiomegaly via thoracic radiography is a necessary criterion for classification of disease severity in dogs with myxomatous mitral valve disease (MMVD). OBJECTIVE: Modified-vertebral left atrial size (M-VLAS) facilitates objective radiographic assessment of the left atrium (LA) in 2 dimensions and identifies LA enlargement more accurately than existing methods. ANIMALS: Sixty-four dogs with various stages of MMVD and 6 control healthy dogs. METHODS: Retrospective case-control study. Medical records were searched for dogs with varying severity of MMVD. Modified-vertebral left atrial size, vertebral left atrial size (VLAS), vertebral heart size (VHS), and radiographic left atrial dimension (RLAD) were measured from thoracic radiographs and compared with echocardiographically derived measurements. RESULTS: Positive correlation to LA/Ao was identified for M-VLAS (r = 0.77, P < .001), VLAS (r = 0.76, P < .001), RLAD (r = 0.75, P < .001), and VHS (r = 0.67, P < .001). Receiver operating characteristic analyzes provided an area under the curve of 0.97 (95% CI, 0.94-1.00) for M-VLAS, which was superior to VHS (0.90, 95% CI, 0.94-1.00, P = .03) in identifying dogs with LA/Ao ≥1.6. A cut-off value of ≥3.4 vertebrae using M-VLAS provided 92.7% sensitivity and 93.1% specificity in predicting LA enlargement. CONCLUSIONS AND CLINICAL IMPORTANCE: M-VLAS, which is superior to VHS, offers an accurate and repeatable way to radiographically identify LA enlargement in dogs with MMVD.
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Lam et al. (2021) conducted a case-control in Myxomatous mitral valve disease (MMVD) (n=70). Modified-vertebral left atrial size (M-VLAS) vs. Vertebral heart size (VHS) was evaluated on Area under the receiver operating characteristic curve (AUC) for identifying left atrial enlargement (LA/Ao ≥1.6) (95% CI 0.94-1.00, p=0.03). Modified-vertebral left atrial size (M-VLAS) provided an area under the curve of 0.97, which was superior to vertebral heart size (AUC 0.90, P=0.03) in identifying left atrial enlargement in dogs.
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