February 1, 1983Acta Physiologica Scandinavica

The glomerular filtration rate in unrestrained rabbits determined by means of an implanted telemetrical device

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Structured PICO

Population

Unrestrained and undisturbed rabbits, and lightly pentobarbital anesthetized rabbits

Intervention

Implanted radio-telemetrical device (Geiger-Müller detector, high voltage supply, FM transmitter) to measure body disappearance rate of 125I-iothalamate following a single i.v. bolus

Comparator

Constant infusion clearance technique using 51Cr-EDTA and inulin

Outcome

Glomerular filtration rate (GFR)surrogate

An implanted telemetrical device can accurately measure GFR in unrestrained rabbits, demonstrating higher GFR in conscious versus anesthetized animals.

Discussion

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Implication

Enables continuous GFR monitoring in conscious rabbits; extends preclinical tools but leaves open human translation.

Cite This Study

Vadstrup et al. (1983) studied this question.

synapsesocial.com/papers/6a914ff862841d9e29fb6520 https://doi.org/10.1111/j.1748-1716.1983.tb07195.x

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