Key result
A multimodal therapeutic regimen including furosemide, pimobendan, benazepril, spironolactone, and dietary modifications led to significant clinical improvement and resolution of coughing in a dog with MMVD.
Why the study?
Does a multimodal treatment regimen including benazepril, spironolactone, furosemide, and pimobendan improve symptoms in a dog with Myxomatous Mitral Valve Disease?
Case Report (n=1)
No
Does a multimodal treatment regimen including benazepril, spironolactone, furosemide, and pimobendan improve symptoms in a dog with Myxomatous Mitral Valve Disease?
Multimodal therapy including ACE inhibitors, diuretics, and positive inotropes, guided by echocardiography and biomarkers, improved clinical symptoms in a dog with Myxomatous Mitral Valve Disease.
Case report of MMVD management in a Shih Tzu; hypothesis-generating and should not yet change practice.
This case report describes the clinical presentation, diagnosis, and management of Myxomatous Mitral Valve Disease (MMVD) in an 8-year-old intact male Shih Tzu named Oreo. Oreo presented with chronic coughing, exercise intolerance, and increased respiratory effort. Diagnostics revealed a Grade IV/VI systolic murmur, cardiomegaly, pulmonary congestion, elevated NT-proBNP and Troponin I along with mitral valve abnormalities on echocardiography. A comprehensive treatment regimen including furosemide, pimobendan, an ACE inhibitor, spironolactone, and dietary modifications led to clinical improvement. This report highlights the significance of early diagnosis and multimodal therapy in managing MMVD in small-breed dogs.
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Nanda et al. (2025) conducted a case report in Myxomatous Mitral Valve Disease (MMVD) (n=1). Multimodal therapy (Benazepril, Spironolactone, Furosemide, Pimobendan, low-sodium diet) was evaluated on Clinical improvement (reduction in pulmonary congestion and resolution of coughing). A multimodal therapeutic regimen including furosemide, pimobendan, benazepril, spironolactone, and dietary modifications led to significant clinical improvement and resolution of coughing in a dog with MMVD.
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