Key result
Severe chronic valvular disease (NYHA class III-IV) in dogs was associated with a significantly lower glomerular filtration rate compared to class I-II (1.7 vs 3.1 mL/min/kg; P≤.001).
Population
148 client-owned dogs with chronic valvular disease
Design
Cohort
Authors
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May warrant renal monitoring in dogs with advanced valvular disease; leaves open cardiorenal parallels in human HF.
Observational (n=148)
Absolute Event Rate: 1.7% vs 3.1%
p-value: p=≤.001
Azotemia and renal impairment are frequent findings in dogs with chronic valvular disease and worsen with the severity of congestive heart failure.
Nicolle et al. (2007) conducted an observational in Chronic valvular heart disease (n=148). Severe chronic valvular disease (NYHA class III-IV) vs. Mild to moderate chronic valvular disease (NYHA class I-II) was evaluated on Glomerular filtration rate (GFR) (p=≤.001). Severe chronic valvular disease (NYHA class III-IV) in dogs was associated with a significantly lower glomerular filtration rate compared to class I-II (1.7 vs 3.1 mL/min/kg; P≤.001).
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