Key result
A 36-year-old man with a rare rectosigmoid Ewing sarcoma was managed with surgical resection followed by chemotherapy.
Why the study?
Ewing sarcoma rarely arises in the gastrointestinal tract, and rectosigmoid presentations are exceptionally uncommon.
Case Report (n=1)
Primary extraosseous Ewing sarcoma of the rectosigmoid region is extremely rare and requires morphology, immunohistochemistry, and molecular testing for diagnosis.
Answers are grounded in this paper and cite their sources.
Raises awareness for rare rectosigmoid Ewing sarcoma in differentials; leaves open optimal management strategies pending larger series.
BACKGROUND: Ewing sarcoma rarely arises in the gastrointestinal (GI) tract, and rectosigmoid presentations are exceptionally uncommon. CASE PRESENTATION: 36-year-old man with rectosigmoid mass showing small round blue cells with pseudorosettes, CD99 and FLI1 positive, diagnosed as Ewing sarcoma; managed with surgical resection followed by chemotherapy. CONCLUSION: Primary EES of rectosigmoid is extremely rare; diagnosis requires morphology, IHC and molecular testing wherever possible; early biopsy allows neoadjuvant chemo before surgery.
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Adhikari et al. (2025) conducted a case report in Primary Extraosseous Ewing sarcoma of the Rectosigmoid region (n=1). Surgical resection followed by chemotherapy was evaluated. A 36-year-old man with a rare rectosigmoid Ewing sarcoma was managed with surgical resection followed by chemotherapy.
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