Key result
A 52-year-old woman was diagnosed with extraskeletal Ewing's sarcoma mimicking sigmoid adenocarcinoma using CD99 staining and EWSR1 translocation testing after negative CT imaging.
Case Report (n=1)
Extraskeletal Ewing's sarcoma can rarely present in older patients mimicking sigmoid adenocarcinoma, requiring immunohistochemical and molecular testing for diagnosis.
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Extraskeletal Ewing sarcoma may mimic sigmoid adenocarcinoma; leaves open the value of CD99/EWSR1 testing in atypical colorectal masses.
INTRODUCTION: Extraskeletal Ewing's sarcoma (EES) is a rare finding in comparison with Ewing's sarcoma of bone and usually manifests in young patients. However, even in older patients, one must consider the diagnosis. PATIENTS AND METHODS: In this case, we describe a 52-year-old woman diagnosed with EES, mimicking as adenocarcinoma of the sigmoid. RESULTS: The tumor was not visualized by a multi-slice spiral computed tomography of the abdomen and pelvis with intravenous contrast, and eventually the diagnosis was made by positive immunohistochemical staining for CD99 and by molecular testing for EWSR1 translocation. CONCLUSIONS: This combination of the patient's age and the localization of the tumor mimicking an adenocarcinoma of the sigmoid has never been described before.
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Mertens et al. (2016) conducted a case report in Extraskeletal Ewing's sarcoma mimicking adenocarcinoma of the sigmoid (n=1). Immunohistochemical staining for CD99 and molecular testing for EWSR1 translocation was evaluated on Diagnosis of extraskeletal Ewing's sarcoma. A 52-year-old woman was diagnosed with extraskeletal Ewing's sarcoma mimicking sigmoid adenocarcinoma using CD99 staining and EWSR1 translocation testing after negative CT imaging.
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