Key result
Wide surgical resection combined with chemotherapy and radiotherapy resulted in no recurrence or metastasis during a 1.5-year follow-up in two female patients with extraskeletal Ewing sarcoma.
Why the study?
Due to its rarity and overlapping clinical features with other malignancies, extraskeletal Ewing sarcoma poses significant diagnostic and therapeutic challenges.
Case Report (n=2)
No
Wide surgical resection combined with chemotherapy and radiotherapy resulted in favorable outcomes with no recurrence or metastasis at 1.5 years in two patients with rare extraskeletal Ewing sarcoma of the upper extremity.
Case report of rare EES illustrates diagnostic pitfalls; leaves open need for prospective data on management.
Extraskeletal Ewing sarcoma (EES) is a rare and aggressive malignancy originating in soft tissues, distinct from osseous Ewing sarcoma. It commonly affects adolescents and young adults but can occur at any age. Due to its rarity and overlapping clinical features with other malignancies, EES poses significant diagnostic and therapeutic challenges. Accurate diagnosis requires a multidisciplinary approach, incorporating imaging, histopathological evaluation, and molecular testing, such as the detection of the EWSR1-FLI1 fusion protein. This case series highlights two instances of EES involving the scapular and arm regions. The clinical presentations, diagnostic workup, and management strategies, including surgery, chemotherapy, and radiotherapy, are detailed. These cases underscore the importance of a collaborative and individualized approach to managing EES. They also contribute valuable insights to the understanding and treatment of this rare malignancy, emphasizing the need for ongoing research and multidisciplinary collaboration in achieving optimal outcomes.
No takes yet. Share an insight, caveat, or question.
Celayir et al. (2024) conducted a case report in Extraskeletal Ewing Sarcoma (n=2). Wide resection, chemotherapy, and radiotherapy was evaluated on Recurrence or metastasis. Wide surgical resection combined with chemotherapy and radiotherapy resulted in no recurrence or metastasis during a 1.5-year follow-up in two female patients with extraskeletal Ewing sarcoma.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: