Key result
Hypertrophic cardiomyopathy was associated with reduced mitral annular area changes (9.5% vs 19%) and apicobasal motion (5.8 mm vs 13.6 mm) compared to normal controls.
Why the study?
Does real time three-dimensional echocardiography reveal differences in mitral annular motion between patients with hypertrophic cardiomyopathy, left ventricular hypertrophy, and normal controls?
Observational (n=30)
Does real time three-dimensional echocardiography reveal differences in mitral annular motion between patients with hypertrophic cardiomyopathy, left ventricular hypertrophy, and normal controls?
RT3DE demonstrates that mitral annular function is preserved in secondary LVH but significantly reduced in hypertrophic cardiomyopathy.
RT3DE may differentiate HCM from secondary LVH by mitral annular motion; leaves open diagnostic utility pending validation.
It has been shown that systolic excursion of the mitral annulus (MA) correlates well with left ventricular (LV) systolic function. Evaluation of the complicated shape and dynamics of the mitral annulus, however, may require rigorous methodology. The aim of this study was to investigate differences in MA motion between hypertrophic cardiomyopathy (HCM) and left ventricular hypertrophy (LVH) patients due to hypertension or aortic stenosis using real time three-dimensional echocardiography (RT3DE). We studied 10 HCM, 10 LVH, and 10 controls. Mean MA area changes between early and late systole were 9.5 +/- 4.3% in HCM, 26 +/- 15% in LVH and 19 +/- 10% in normal controls. MA apicobasal motion was 5.8 +/- 4 mm in HCM, 11 +/- 4 mm in LVH, and 13.6 +/- 6 mm in normal controls. RT3DE with digital reconstruction of MA accurately display complicated MA geometry and dynamics during a cardiac cycle. Annular function in LVH was similar to that of the normal group while annular apicobasal motion and area changes were reduced in HCM.
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Yalçın et al. (2008) conducted an observational in Myocardial Hypertrophy (n=30). Hypertrophic cardiomyopathy (HCM) and left ventricular hypertrophy (LVH) vs. Normal controls was evaluated on Mean mitral annular area changes between early and late systole. Hypertrophic cardiomyopathy was associated with reduced mitral annular area changes (9.5% vs 19%) and apicobasal motion (5.8 mm vs 13.6 mm) compared to normal controls.
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