What is the clinical evidence from this study?

Study design: Other. Primary outcome: Mapping of regions within the C-terminus which interact with the N-terminus of Kir6.2.

October 30, 2001FEBS Letters

Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2

View Full Paper

Ask AI

Bookmark

Key result

In vitro protein-protein interaction assays identified multiple interaction domains within the C-terminus of Kir6.2 (CID1, CID2, and CID3) that interact with the N-terminus.

Population

In vitro protein-protein interaction assay for Kir6.2 potassium channel

Design

Preclinical

Authors

PJPhillippa A Jones STStephen J. Tucker FAFrances M. Ashcroft

Discussion

Member takes

Overview

No immediate clinical implications; leaves open functional roles of CID1-3 in human KATP channelopathies.

Structured PICO

Population

In vitro protein-protein interaction assay for Kir6.2 potassium channel

Intervention

Mapping of regions within the C-terminus that interact with the N-terminus

Outcome

Identification of interaction domains within the C-terminus

Identifies multiple interaction domains between the N- and C-termini of the Kir6.2 potassium channel, providing insight into channel assembly and gating.

Cite This Study

Jones et al. (2001) studied this question. In vitro protein-protein interaction assays identified multiple interaction domains within the C-terminus of Kir6.2 (CID1, CID2, and CID3) that interact with the N-terminus.

synapsesocial.com/papers/6a9155abbe68d22e6965ef71 https://doi.org/10.1016/s0014-5793(01)03023-x

View Full Paper

Ask AI

Bookmark

October 30, 2001FEBS Letters

Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2

View Full Paper

Ask AI

Bookmark

Key result

In vitro protein-protein interaction assays identified multiple interaction domains within the C-terminus of Kir6.2 (CID1, CID2, and CID3) that interact with the N-terminus.

Population

In vitro protein-protein interaction assay for Kir6.2 potassium channel

Design

Preclinical

Authors

PJPhillippa A Jones STStephen J. Tucker FAFrances M. Ashcroft

Discussion

Member takes

Overview

No immediate clinical implications; leaves open functional roles of CID1-3 in human KATP channelopathies.

Structured PICO

Population

In vitro protein-protein interaction assay for Kir6.2 potassium channel

Intervention

Mapping of regions within the C-terminus that interact with the N-terminus

Outcome

Identification of interaction domains within the C-terminus

Identifies multiple interaction domains between the N- and C-termini of the Kir6.2 potassium channel, providing insight into channel assembly and gating.

Cite This Study

synapsesocial.com/papers/6a9155abbe68d22e6965ef71 https://doi.org/10.1016/s0014-5793(01)03023-x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark