This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone labeled with tritium was incorporated into a commercial preparation. The concentration of drug reached a peak of 7.651μg/gm of aqueous humor at 30 minutes and decreased to a level of 2.176μg/gm at 240 minutes. These results are compared with the penetration of tritiated dexamethasone.
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P. W. MURDICK (1966) studied this question.
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