Key result
Simulated vagotomy increased both inspiratory and expiratory durations, while combined vagotomy and pontine suppression resulted in apneusis characterized by significantly prolonged inspiration.
Population
Computational model of the mammalian brainstem respiratory network, extending the Smith et al. model by…
Comparison
Simulated perturbations: 'vagotomy', suppression… vs Model operation under normal conditions with…
Design
Preclinical
Authors
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Should not change clinical respiratory management; leaves open translation of pontine-vagal feedback models to human breathing disorders.
A computational model demonstrates that interacting pontine and pulmonary feedback loops control respiratory phase durations, and their combined disruption leads to apneusis.
Molkov et al. (2013) studied Respiratory pattern generation. Simulated vagotomy and/or suppression of pontine activity vs. Intact model (normal conditions) was evaluated on Durations of inspiration (TI) and expiration (TE). Simulated vagotomy increased both inspiratory and expiratory durations, while combined vagotomy and pontine suppression resulted in apneusis characterized by significantly prolonged inspiration.
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