Why the study?
Does cooling affect norepinephrine- and KCl-induced vasoconstriction in isolated simian and canine femoral arteries and veins?
Does cooling affect norepinephrine- and KCl-induced vasoconstriction in isolated simian and canine femoral arteries and veins?
Cooling from 37°C to 27°C depresses vasoconstriction in femoral arteries but not in femoral veins across both canine and simian models.
Cooling may spare venous tone in large-mammal vessels; leaves open translation to human thermoregulation or perioperative vasomotor management.
Using the cannula inserting method, effects of cooling (from 37 degrees C to 27 degrees C) on norepinephrine (NE)- and KCI-induced vasoconstrictions were investigated in isolated, perfused simian and canine femoral arteries and veins. KCI-induced constrictions were much greater in simian vessels than in canine vessels. NE-induced constrictions were similar in both arteries, but were greater in simian veins than in canine veins. In both arteries, NE- and KCI-induced vasoconstrictions were markedly depressed to almost the same degree by cooling. In both veins, the vasoconstrictions were not significantly affected by cooling.
No takes yet. Share an insight, caveat, or question.
Kawai et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: