Key result
Local cooling augmented venoconstrictor responses to various stimuli in dogs, an effect that cannot be explained by inhibition of norepinephrine re-uptake by nerve terminals.
Why the study?
Does local cooling augment venoconstrictor responses in dogs via inhibition of norepinephrine reuptake?
Does local cooling augment venoconstrictor responses in dogs via inhibition of norepinephrine reuptake?
The sensitizing effect of cold on venous smooth muscle cannot be explained by inhibition of norepinephrine re-uptake by nerve terminals.
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Rules out norepinephrine reuptake inhibition as the mechanism in dogs; leaves open alternative pathways and human relevance.
Michael M. Webb‐Peploe (1969) studied this question. Local cooling was evaluated on Venomotor responses (changes in driving pressure of the saphenous vein). Local cooling augmented venoconstrictor responses to various stimuli in dogs, an effect that cannot be explained by inhibition of norepinephrine re-uptake by nerve terminals.