Key result
Inhibition of monoamine oxidase and catechol-O-methyl transferase increased venous response to adrenergic stimulation but did not alter the potentiating effect of local cooling.
Why the study?
Does inhibition of monoamine oxidase or catechol-O-methyl transferase alter the thermosensitivity of canine cutaneous veins to adrenergic stimulation?
Does inhibition of monoamine oxidase or catechol-O-methyl transferase alter the thermosensitivity of canine cutaneous veins to adrenergic stimulation?
The potentiating effect of local cooling on cutaneous vein responses to adrenergic stimulation is not explained by interference with local enzymatic inactivation of catecholamines.
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Does not implicate MAO/COMT in cooling potentiation of cutaneous veins; leaves open alternative mechanisms for adrenergic thermosensitivity.
Vanhoutte et al. (1969) studied this question. Tranylcypromine and pyrogallol was evaluated on Active changes in venous tone (driving pressure) in response to adrenergic stimulation and cooling. Inhibition of monoamine oxidase and catechol-O-methyl transferase increased venous response to adrenergic stimulation but did not alter the potentiating effect of local cooling.
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