Why the study?
Does cooling from 37°C to 27°C alter norepinephrine- and KCl-induced vasoconstriction in isolated simian and canine femoral vessels?
Does cooling from 37°C to 27°C alter norepinephrine- and KCl-induced vasoconstriction in isolated simian and canine femoral vessels?
Cooling from 37°C to 27°C selectively depresses vasoconstriction in femoral arteries but not veins in both canine and simian models.
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Cooling selectively attenuates arterial vasoconstriction in large-animal ex vivo models; leaves open relevance to human thermoregulation or therapeutic hypothermia.
Using the cannula inserting method, effects of cooling (from 37°C to 27°C) on norepinephrine (NE)- and KCI-induced vasoconstrictions were investigated in isolated, perfused simian and canine femoral arteries and veins. KCI-induced constrictions were much greater in simian vessels than in canine vessels. NE-induced constrictions were similar in both arteries, but were greater in simian veins than in canine veins. In both arteries, NE- and KCI-induced vasoconstrictions were markedly depressed to almost the same degree by cooling. In both veins, the vasoconstrictions were not significantly affected by cooling.
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Kawai et al. (1989) studied this question.
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