Key result
Acidosis at a low temperature (25°C) did not inhibit noradrenaline-induced tone and significantly increased neurogenic contraction of rat tail artery segments, reversing its typical vasodilatory effect.
Why the study?
Although acidosis-evoked vasodilation at normal body temperature is recognized, reports regarding the effect of acidosis on isolated artery reactivity at low temperatures are nonexistent.
Does acidosis combined with low temperature affect noradrenaline-induced and neurogenic constriction in the isolated rat tail artery?
Does acidosis combined with low temperature affect noradrenaline-induced and neurogenic constriction in the isolated rat tail artery?
Acidosis at low temperatures paradoxically increases neurogenic vasoconstriction in the rat tail artery, which may be an important physiological mechanism for reducing heat loss in cold environments.
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No immediate clinical implications for hypothermic or acidotic states; leaves open whether cooling augments acidosis effects on human vascular reactivity.
Vladimir N. Yartsev (2021) studied this question. Acidosis and cooling vs. Normal pH (7.4) and temperature (37°C) was evaluated on Neurogenic and noradrenaline-induced vasoconstriction. Acidosis at a low temperature (25°C) did not inhibit noradrenaline-induced tone and significantly increased neurogenic contraction of rat tail artery segments, reversing its typical vasodilatory effect.
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