Why the study?
Does respiratory acidosis induced by carbon dioxide inhalation reduce peripheral vascular reactivity to noradrenaline in cats?
Population
Cats (hind leg perfused in situ with constant outflow pump using own blood, and intact animals)
Comparison
Inhalation of carbon dioxide to induce… vs Baseline state without carbon dioxide inhalation
Design
Preclinical
Authors
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Attenuates noradrenaline vasoconstriction during hypercapnia in cats; leaves open relevance to human vasopressor dosing in acidotic states.
Does respiratory acidosis induced by carbon dioxide inhalation reduce peripheral vascular reactivity to noradrenaline in cats?
Respiratory acidosis significantly reduces peripheral vascular reactivity to noradrenaline, which explains the decreased effectiveness of intravenous noradrenaline on blood pressure during this state.
Bygdeman et al. (1962) studied this question.
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